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faecium atcc 19434 hc50  (ATCC)


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    Structured Review

    ATCC faecium atcc 19434 hc50
    Faecium Atcc 19434 Hc50, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 616 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/faecium+atcc+19434+hc50/Enterococcus+faecium/us08795647-120-363-364
    Average 96 stars, based on 616 article reviews
    faecium atcc 19434 hc50 - by Bioz Stars, 2026-09
    96/100 stars

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    Polymer:

    Article Title: Alternating ring-opening metathesis polymerization
    Article Snippet: .. TABLE 1 AROMP Polymer Preparationsa [Ru] Reaction % A B (M) [A]:[B]:[Ru] time (h) Product conv.b 2 none 0.01 10:0:1 5 4 10 2 none 0.067 1:0:1.5 20 4 55c 2 5 0.05 3:6:1 6 6a 74c 2 5 0.01 10:20:1 3 6b 98 2 5 0.01 20:40:1 3 6c 98 none 5 0.01 0:40:1 6 NRd 0 2 5 0.01 50:100:1 3 6d 98 2 5 0.01 100:200:1 3 6e 97 2 5 0.005 200:400:1 6 6f 73 2 5 0.01 200:400:1 6 6f 75 2 7 0.01 20:24:1 3 8c 97 2 7 0.01 20:40:1 3 8c 97 2 7 0.01 20:160:1 3 8c 97 2 9 0.01 10:20:1 3 NR 0 2 10 0.01 10:20:1 3 NR 0 11 5 0.01 20:40:1 4 12c 96 13 5 0.01 10:20:1 13 14b 95 2 15 0.01 20:40:1 4 16c 95 2 17 0.01 20:40:1 4 18c 95 2 19 0.01 20:40:1 6 20c 90 21 5 0.01 25:50:1 5 22g 90 21 15 0.01 25:50:1 3e 29g 94 21 26 0.01 25:50:1 3e 31g 92 21 27 0.01 25:50:1 5e 33g 96 24 5 0.01 25:50:1 1.5e 35g 97 25 5 0.01 25:50:1 1.5e 37g 97 21 5 0.01 25:50:1 5f 39g 90 21 42 0.01 20:40:1 3g 43c 50 aAROMP reactions were performed in CD2Cl2 and monitored by 1H-NMR spectroscopy at room temperature. bPercent conversion determined by integration of 1H-NMR spectra unless specified otherwise. cAROMP reactions were performed in CH2Cl2, and the isolated yield was determined after flash column chromatography purification. dNR: no reaction. eReaction temperature: 50° C., solvent: CDCl3 fCatalyst: Hoveyda-Grubbs 2nd Generation catalyst 28 gReaction temperature: 50° C., solvent: CDCl3, Catalyst: 41 TABLE 2 Minimum Inhibitory Concentrations (MIC)a and HC50b 23g 30g 32g 34g 40g 36g 38g Strain (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) Pseudomonas 64 >64 >64 >64 >64 128 32 aeruginosa ATCC 27853 Escherichia coli 16 64 >64 >64 >64 64 8 ATCC 25922 Bacillus cereus 8 16 >64 32 64 64 8 ATCC 10987 Staphylococcus 4 8 >64 32 16 32 4 aureus ATCC 25923 Enterococcus 4 16 >64 32 32 64 8 faecalis ATCC 19433 Enterococcus 4 16 >64 32 32 32 8 faecium ATCC 19434 HC50 256 768 >1024 192 1024 1024 512 aIndicated strains were incubated with an aqueous solution of 23g for 18 h, and the lowest concentration at which no growth is detected is reported. bHemolytic activity towards red blood cells (HC50 = concentration at which 50% of blood cells are lysed) ..

    Spectroscopy:

    Article Title: Alternating ring-opening metathesis polymerization
    Article Snippet: .. TABLE 1 AROMP Polymer Preparationsa [Ru] Reaction % A B (M) [A]:[B]:[Ru] time (h) Product conv.b 2 none 0.01 10:0:1 5 4 10 2 none 0.067 1:0:1.5 20 4 55c 2 5 0.05 3:6:1 6 6a 74c 2 5 0.01 10:20:1 3 6b 98 2 5 0.01 20:40:1 3 6c 98 none 5 0.01 0:40:1 6 NRd 0 2 5 0.01 50:100:1 3 6d 98 2 5 0.01 100:200:1 3 6e 97 2 5 0.005 200:400:1 6 6f 73 2 5 0.01 200:400:1 6 6f 75 2 7 0.01 20:24:1 3 8c 97 2 7 0.01 20:40:1 3 8c 97 2 7 0.01 20:160:1 3 8c 97 2 9 0.01 10:20:1 3 NR 0 2 10 0.01 10:20:1 3 NR 0 11 5 0.01 20:40:1 4 12c 96 13 5 0.01 10:20:1 13 14b 95 2 15 0.01 20:40:1 4 16c 95 2 17 0.01 20:40:1 4 18c 95 2 19 0.01 20:40:1 6 20c 90 21 5 0.01 25:50:1 5 22g 90 21 15 0.01 25:50:1 3e 29g 94 21 26 0.01 25:50:1 3e 31g 92 21 27 0.01 25:50:1 5e 33g 96 24 5 0.01 25:50:1 1.5e 35g 97 25 5 0.01 25:50:1 1.5e 37g 97 21 5 0.01 25:50:1 5f 39g 90 21 42 0.01 20:40:1 3g 43c 50 aAROMP reactions were performed in CD2Cl2 and monitored by 1H-NMR spectroscopy at room temperature. bPercent conversion determined by integration of 1H-NMR spectra unless specified otherwise. cAROMP reactions were performed in CH2Cl2, and the isolated yield was determined after flash column chromatography purification. dNR: no reaction. eReaction temperature: 50° C., solvent: CDCl3 fCatalyst: Hoveyda-Grubbs 2nd Generation catalyst 28 gReaction temperature: 50° C., solvent: CDCl3, Catalyst: 41 TABLE 2 Minimum Inhibitory Concentrations (MIC)a and HC50b 23g 30g 32g 34g 40g 36g 38g Strain (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) Pseudomonas 64 >64 >64 >64 >64 128 32 aeruginosa ATCC 27853 Escherichia coli 16 64 >64 >64 >64 64 8 ATCC 25922 Bacillus cereus 8 16 >64 32 64 64 8 ATCC 10987 Staphylococcus 4 8 >64 32 16 32 4 aureus ATCC 25923 Enterococcus 4 16 >64 32 32 64 8 faecalis ATCC 19433 Enterococcus 4 16 >64 32 32 32 8 faecium ATCC 19434 HC50 256 768 >1024 192 1024 1024 512 aIndicated strains were incubated with an aqueous solution of 23g for 18 h, and the lowest concentration at which no growth is detected is reported. bHemolytic activity towards red blood cells (HC50 = concentration at which 50% of blood cells are lysed) ..

    Isolation:

    Article Title: Alternating ring-opening metathesis polymerization
    Article Snippet: .. TABLE 1 AROMP Polymer Preparationsa [Ru] Reaction % A B (M) [A]:[B]:[Ru] time (h) Product conv.b 2 none 0.01 10:0:1 5 4 10 2 none 0.067 1:0:1.5 20 4 55c 2 5 0.05 3:6:1 6 6a 74c 2 5 0.01 10:20:1 3 6b 98 2 5 0.01 20:40:1 3 6c 98 none 5 0.01 0:40:1 6 NRd 0 2 5 0.01 50:100:1 3 6d 98 2 5 0.01 100:200:1 3 6e 97 2 5 0.005 200:400:1 6 6f 73 2 5 0.01 200:400:1 6 6f 75 2 7 0.01 20:24:1 3 8c 97 2 7 0.01 20:40:1 3 8c 97 2 7 0.01 20:160:1 3 8c 97 2 9 0.01 10:20:1 3 NR 0 2 10 0.01 10:20:1 3 NR 0 11 5 0.01 20:40:1 4 12c 96 13 5 0.01 10:20:1 13 14b 95 2 15 0.01 20:40:1 4 16c 95 2 17 0.01 20:40:1 4 18c 95 2 19 0.01 20:40:1 6 20c 90 21 5 0.01 25:50:1 5 22g 90 21 15 0.01 25:50:1 3e 29g 94 21 26 0.01 25:50:1 3e 31g 92 21 27 0.01 25:50:1 5e 33g 96 24 5 0.01 25:50:1 1.5e 35g 97 25 5 0.01 25:50:1 1.5e 37g 97 21 5 0.01 25:50:1 5f 39g 90 21 42 0.01 20:40:1 3g 43c 50 aAROMP reactions were performed in CD2Cl2 and monitored by 1H-NMR spectroscopy at room temperature. bPercent conversion determined by integration of 1H-NMR spectra unless specified otherwise. cAROMP reactions were performed in CH2Cl2, and the isolated yield was determined after flash column chromatography purification. dNR: no reaction. eReaction temperature: 50° C., solvent: CDCl3 fCatalyst: Hoveyda-Grubbs 2nd Generation catalyst 28 gReaction temperature: 50° C., solvent: CDCl3, Catalyst: 41 TABLE 2 Minimum Inhibitory Concentrations (MIC)a and HC50b 23g 30g 32g 34g 40g 36g 38g Strain (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) Pseudomonas 64 >64 >64 >64 >64 128 32 aeruginosa ATCC 27853 Escherichia coli 16 64 >64 >64 >64 64 8 ATCC 25922 Bacillus cereus 8 16 >64 32 64 64 8 ATCC 10987 Staphylococcus 4 8 >64 32 16 32 4 aureus ATCC 25923 Enterococcus 4 16 >64 32 32 64 8 faecalis ATCC 19433 Enterococcus 4 16 >64 32 32 32 8 faecium ATCC 19434 HC50 256 768 >1024 192 1024 1024 512 aIndicated strains were incubated with an aqueous solution of 23g for 18 h, and the lowest concentration at which no growth is detected is reported. bHemolytic activity towards red blood cells (HC50 = concentration at which 50% of blood cells are lysed) ..

    Column Chromatography:

    Article Title: Alternating ring-opening metathesis polymerization
    Article Snippet: .. TABLE 1 AROMP Polymer Preparationsa [Ru] Reaction % A B (M) [A]:[B]:[Ru] time (h) Product conv.b 2 none 0.01 10:0:1 5 4 10 2 none 0.067 1:0:1.5 20 4 55c 2 5 0.05 3:6:1 6 6a 74c 2 5 0.01 10:20:1 3 6b 98 2 5 0.01 20:40:1 3 6c 98 none 5 0.01 0:40:1 6 NRd 0 2 5 0.01 50:100:1 3 6d 98 2 5 0.01 100:200:1 3 6e 97 2 5 0.005 200:400:1 6 6f 73 2 5 0.01 200:400:1 6 6f 75 2 7 0.01 20:24:1 3 8c 97 2 7 0.01 20:40:1 3 8c 97 2 7 0.01 20:160:1 3 8c 97 2 9 0.01 10:20:1 3 NR 0 2 10 0.01 10:20:1 3 NR 0 11 5 0.01 20:40:1 4 12c 96 13 5 0.01 10:20:1 13 14b 95 2 15 0.01 20:40:1 4 16c 95 2 17 0.01 20:40:1 4 18c 95 2 19 0.01 20:40:1 6 20c 90 21 5 0.01 25:50:1 5 22g 90 21 15 0.01 25:50:1 3e 29g 94 21 26 0.01 25:50:1 3e 31g 92 21 27 0.01 25:50:1 5e 33g 96 24 5 0.01 25:50:1 1.5e 35g 97 25 5 0.01 25:50:1 1.5e 37g 97 21 5 0.01 25:50:1 5f 39g 90 21 42 0.01 20:40:1 3g 43c 50 aAROMP reactions were performed in CD2Cl2 and monitored by 1H-NMR spectroscopy at room temperature. bPercent conversion determined by integration of 1H-NMR spectra unless specified otherwise. cAROMP reactions were performed in CH2Cl2, and the isolated yield was determined after flash column chromatography purification. dNR: no reaction. eReaction temperature: 50° C., solvent: CDCl3 fCatalyst: Hoveyda-Grubbs 2nd Generation catalyst 28 gReaction temperature: 50° C., solvent: CDCl3, Catalyst: 41 TABLE 2 Minimum Inhibitory Concentrations (MIC)a and HC50b 23g 30g 32g 34g 40g 36g 38g Strain (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) Pseudomonas 64 >64 >64 >64 >64 128 32 aeruginosa ATCC 27853 Escherichia coli 16 64 >64 >64 >64 64 8 ATCC 25922 Bacillus cereus 8 16 >64 32 64 64 8 ATCC 10987 Staphylococcus 4 8 >64 32 16 32 4 aureus ATCC 25923 Enterococcus 4 16 >64 32 32 64 8 faecalis ATCC 19433 Enterococcus 4 16 >64 32 32 32 8 faecium ATCC 19434 HC50 256 768 >1024 192 1024 1024 512 aIndicated strains were incubated with an aqueous solution of 23g for 18 h, and the lowest concentration at which no growth is detected is reported. bHemolytic activity towards red blood cells (HC50 = concentration at which 50% of blood cells are lysed) ..

    Purification:

    Article Title: Alternating ring-opening metathesis polymerization
    Article Snippet: .. TABLE 1 AROMP Polymer Preparationsa [Ru] Reaction % A B (M) [A]:[B]:[Ru] time (h) Product conv.b 2 none 0.01 10:0:1 5 4 10 2 none 0.067 1:0:1.5 20 4 55c 2 5 0.05 3:6:1 6 6a 74c 2 5 0.01 10:20:1 3 6b 98 2 5 0.01 20:40:1 3 6c 98 none 5 0.01 0:40:1 6 NRd 0 2 5 0.01 50:100:1 3 6d 98 2 5 0.01 100:200:1 3 6e 97 2 5 0.005 200:400:1 6 6f 73 2 5 0.01 200:400:1 6 6f 75 2 7 0.01 20:24:1 3 8c 97 2 7 0.01 20:40:1 3 8c 97 2 7 0.01 20:160:1 3 8c 97 2 9 0.01 10:20:1 3 NR 0 2 10 0.01 10:20:1 3 NR 0 11 5 0.01 20:40:1 4 12c 96 13 5 0.01 10:20:1 13 14b 95 2 15 0.01 20:40:1 4 16c 95 2 17 0.01 20:40:1 4 18c 95 2 19 0.01 20:40:1 6 20c 90 21 5 0.01 25:50:1 5 22g 90 21 15 0.01 25:50:1 3e 29g 94 21 26 0.01 25:50:1 3e 31g 92 21 27 0.01 25:50:1 5e 33g 96 24 5 0.01 25:50:1 1.5e 35g 97 25 5 0.01 25:50:1 1.5e 37g 97 21 5 0.01 25:50:1 5f 39g 90 21 42 0.01 20:40:1 3g 43c 50 aAROMP reactions were performed in CD2Cl2 and monitored by 1H-NMR spectroscopy at room temperature. bPercent conversion determined by integration of 1H-NMR spectra unless specified otherwise. cAROMP reactions were performed in CH2Cl2, and the isolated yield was determined after flash column chromatography purification. dNR: no reaction. eReaction temperature: 50° C., solvent: CDCl3 fCatalyst: Hoveyda-Grubbs 2nd Generation catalyst 28 gReaction temperature: 50° C., solvent: CDCl3, Catalyst: 41 TABLE 2 Minimum Inhibitory Concentrations (MIC)a and HC50b 23g 30g 32g 34g 40g 36g 38g Strain (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) Pseudomonas 64 >64 >64 >64 >64 128 32 aeruginosa ATCC 27853 Escherichia coli 16 64 >64 >64 >64 64 8 ATCC 25922 Bacillus cereus 8 16 >64 32 64 64 8 ATCC 10987 Staphylococcus 4 8 >64 32 16 32 4 aureus ATCC 25923 Enterococcus 4 16 >64 32 32 64 8 faecalis ATCC 19433 Enterococcus 4 16 >64 32 32 32 8 faecium ATCC 19434 HC50 256 768 >1024 192 1024 1024 512 aIndicated strains were incubated with an aqueous solution of 23g for 18 h, and the lowest concentration at which no growth is detected is reported. bHemolytic activity towards red blood cells (HC50 = concentration at which 50% of blood cells are lysed) ..

    Solvent:

    Article Title: Alternating ring-opening metathesis polymerization
    Article Snippet: .. TABLE 1 AROMP Polymer Preparationsa [Ru] Reaction % A B (M) [A]:[B]:[Ru] time (h) Product conv.b 2 none 0.01 10:0:1 5 4 10 2 none 0.067 1:0:1.5 20 4 55c 2 5 0.05 3:6:1 6 6a 74c 2 5 0.01 10:20:1 3 6b 98 2 5 0.01 20:40:1 3 6c 98 none 5 0.01 0:40:1 6 NRd 0 2 5 0.01 50:100:1 3 6d 98 2 5 0.01 100:200:1 3 6e 97 2 5 0.005 200:400:1 6 6f 73 2 5 0.01 200:400:1 6 6f 75 2 7 0.01 20:24:1 3 8c 97 2 7 0.01 20:40:1 3 8c 97 2 7 0.01 20:160:1 3 8c 97 2 9 0.01 10:20:1 3 NR 0 2 10 0.01 10:20:1 3 NR 0 11 5 0.01 20:40:1 4 12c 96 13 5 0.01 10:20:1 13 14b 95 2 15 0.01 20:40:1 4 16c 95 2 17 0.01 20:40:1 4 18c 95 2 19 0.01 20:40:1 6 20c 90 21 5 0.01 25:50:1 5 22g 90 21 15 0.01 25:50:1 3e 29g 94 21 26 0.01 25:50:1 3e 31g 92 21 27 0.01 25:50:1 5e 33g 96 24 5 0.01 25:50:1 1.5e 35g 97 25 5 0.01 25:50:1 1.5e 37g 97 21 5 0.01 25:50:1 5f 39g 90 21 42 0.01 20:40:1 3g 43c 50 aAROMP reactions were performed in CD2Cl2 and monitored by 1H-NMR spectroscopy at room temperature. bPercent conversion determined by integration of 1H-NMR spectra unless specified otherwise. cAROMP reactions were performed in CH2Cl2, and the isolated yield was determined after flash column chromatography purification. dNR: no reaction. eReaction temperature: 50° C., solvent: CDCl3 fCatalyst: Hoveyda-Grubbs 2nd Generation catalyst 28 gReaction temperature: 50° C., solvent: CDCl3, Catalyst: 41 TABLE 2 Minimum Inhibitory Concentrations (MIC)a and HC50b 23g 30g 32g 34g 40g 36g 38g Strain (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) Pseudomonas 64 >64 >64 >64 >64 128 32 aeruginosa ATCC 27853 Escherichia coli 16 64 >64 >64 >64 64 8 ATCC 25922 Bacillus cereus 8 16 >64 32 64 64 8 ATCC 10987 Staphylococcus 4 8 >64 32 16 32 4 aureus ATCC 25923 Enterococcus 4 16 >64 32 32 64 8 faecalis ATCC 19433 Enterococcus 4 16 >64 32 32 32 8 faecium ATCC 19434 HC50 256 768 >1024 192 1024 1024 512 aIndicated strains were incubated with an aqueous solution of 23g for 18 h, and the lowest concentration at which no growth is detected is reported. bHemolytic activity towards red blood cells (HC50 = concentration at which 50% of blood cells are lysed) ..

    Incubation:

    Article Title: Alternating ring-opening metathesis polymerization
    Article Snippet: .. TABLE 1 AROMP Polymer Preparationsa [Ru] Reaction % A B (M) [A]:[B]:[Ru] time (h) Product conv.b 2 none 0.01 10:0:1 5 4 10 2 none 0.067 1:0:1.5 20 4 55c 2 5 0.05 3:6:1 6 6a 74c 2 5 0.01 10:20:1 3 6b 98 2 5 0.01 20:40:1 3 6c 98 none 5 0.01 0:40:1 6 NRd 0 2 5 0.01 50:100:1 3 6d 98 2 5 0.01 100:200:1 3 6e 97 2 5 0.005 200:400:1 6 6f 73 2 5 0.01 200:400:1 6 6f 75 2 7 0.01 20:24:1 3 8c 97 2 7 0.01 20:40:1 3 8c 97 2 7 0.01 20:160:1 3 8c 97 2 9 0.01 10:20:1 3 NR 0 2 10 0.01 10:20:1 3 NR 0 11 5 0.01 20:40:1 4 12c 96 13 5 0.01 10:20:1 13 14b 95 2 15 0.01 20:40:1 4 16c 95 2 17 0.01 20:40:1 4 18c 95 2 19 0.01 20:40:1 6 20c 90 21 5 0.01 25:50:1 5 22g 90 21 15 0.01 25:50:1 3e 29g 94 21 26 0.01 25:50:1 3e 31g 92 21 27 0.01 25:50:1 5e 33g 96 24 5 0.01 25:50:1 1.5e 35g 97 25 5 0.01 25:50:1 1.5e 37g 97 21 5 0.01 25:50:1 5f 39g 90 21 42 0.01 20:40:1 3g 43c 50 aAROMP reactions were performed in CD2Cl2 and monitored by 1H-NMR spectroscopy at room temperature. bPercent conversion determined by integration of 1H-NMR spectra unless specified otherwise. cAROMP reactions were performed in CH2Cl2, and the isolated yield was determined after flash column chromatography purification. dNR: no reaction. eReaction temperature: 50° C., solvent: CDCl3 fCatalyst: Hoveyda-Grubbs 2nd Generation catalyst 28 gReaction temperature: 50° C., solvent: CDCl3, Catalyst: 41 TABLE 2 Minimum Inhibitory Concentrations (MIC)a and HC50b 23g 30g 32g 34g 40g 36g 38g Strain (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) Pseudomonas 64 >64 >64 >64 >64 128 32 aeruginosa ATCC 27853 Escherichia coli 16 64 >64 >64 >64 64 8 ATCC 25922 Bacillus cereus 8 16 >64 32 64 64 8 ATCC 10987 Staphylococcus 4 8 >64 32 16 32 4 aureus ATCC 25923 Enterococcus 4 16 >64 32 32 64 8 faecalis ATCC 19433 Enterococcus 4 16 >64 32 32 32 8 faecium ATCC 19434 HC50 256 768 >1024 192 1024 1024 512 aIndicated strains were incubated with an aqueous solution of 23g for 18 h, and the lowest concentration at which no growth is detected is reported. bHemolytic activity towards red blood cells (HC50 = concentration at which 50% of blood cells are lysed) ..

    Concentration Assay:

    Article Title: Alternating ring-opening metathesis polymerization
    Article Snippet: .. TABLE 1 AROMP Polymer Preparationsa [Ru] Reaction % A B (M) [A]:[B]:[Ru] time (h) Product conv.b 2 none 0.01 10:0:1 5 4 10 2 none 0.067 1:0:1.5 20 4 55c 2 5 0.05 3:6:1 6 6a 74c 2 5 0.01 10:20:1 3 6b 98 2 5 0.01 20:40:1 3 6c 98 none 5 0.01 0:40:1 6 NRd 0 2 5 0.01 50:100:1 3 6d 98 2 5 0.01 100:200:1 3 6e 97 2 5 0.005 200:400:1 6 6f 73 2 5 0.01 200:400:1 6 6f 75 2 7 0.01 20:24:1 3 8c 97 2 7 0.01 20:40:1 3 8c 97 2 7 0.01 20:160:1 3 8c 97 2 9 0.01 10:20:1 3 NR 0 2 10 0.01 10:20:1 3 NR 0 11 5 0.01 20:40:1 4 12c 96 13 5 0.01 10:20:1 13 14b 95 2 15 0.01 20:40:1 4 16c 95 2 17 0.01 20:40:1 4 18c 95 2 19 0.01 20:40:1 6 20c 90 21 5 0.01 25:50:1 5 22g 90 21 15 0.01 25:50:1 3e 29g 94 21 26 0.01 25:50:1 3e 31g 92 21 27 0.01 25:50:1 5e 33g 96 24 5 0.01 25:50:1 1.5e 35g 97 25 5 0.01 25:50:1 1.5e 37g 97 21 5 0.01 25:50:1 5f 39g 90 21 42 0.01 20:40:1 3g 43c 50 aAROMP reactions were performed in CD2Cl2 and monitored by 1H-NMR spectroscopy at room temperature. bPercent conversion determined by integration of 1H-NMR spectra unless specified otherwise. cAROMP reactions were performed in CH2Cl2, and the isolated yield was determined after flash column chromatography purification. dNR: no reaction. eReaction temperature: 50° C., solvent: CDCl3 fCatalyst: Hoveyda-Grubbs 2nd Generation catalyst 28 gReaction temperature: 50° C., solvent: CDCl3, Catalyst: 41 TABLE 2 Minimum Inhibitory Concentrations (MIC)a and HC50b 23g 30g 32g 34g 40g 36g 38g Strain (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) Pseudomonas 64 >64 >64 >64 >64 128 32 aeruginosa ATCC 27853 Escherichia coli 16 64 >64 >64 >64 64 8 ATCC 25922 Bacillus cereus 8 16 >64 32 64 64 8 ATCC 10987 Staphylococcus 4 8 >64 32 16 32 4 aureus ATCC 25923 Enterococcus 4 16 >64 32 32 64 8 faecalis ATCC 19433 Enterococcus 4 16 >64 32 32 32 8 faecium ATCC 19434 HC50 256 768 >1024 192 1024 1024 512 aIndicated strains were incubated with an aqueous solution of 23g for 18 h, and the lowest concentration at which no growth is detected is reported. bHemolytic activity towards red blood cells (HC50 = concentration at which 50% of blood cells are lysed) ..

    Activity Assay:

    Article Title: Alternating ring-opening metathesis polymerization
    Article Snippet: .. TABLE 1 AROMP Polymer Preparationsa [Ru] Reaction % A B (M) [A]:[B]:[Ru] time (h) Product conv.b 2 none 0.01 10:0:1 5 4 10 2 none 0.067 1:0:1.5 20 4 55c 2 5 0.05 3:6:1 6 6a 74c 2 5 0.01 10:20:1 3 6b 98 2 5 0.01 20:40:1 3 6c 98 none 5 0.01 0:40:1 6 NRd 0 2 5 0.01 50:100:1 3 6d 98 2 5 0.01 100:200:1 3 6e 97 2 5 0.005 200:400:1 6 6f 73 2 5 0.01 200:400:1 6 6f 75 2 7 0.01 20:24:1 3 8c 97 2 7 0.01 20:40:1 3 8c 97 2 7 0.01 20:160:1 3 8c 97 2 9 0.01 10:20:1 3 NR 0 2 10 0.01 10:20:1 3 NR 0 11 5 0.01 20:40:1 4 12c 96 13 5 0.01 10:20:1 13 14b 95 2 15 0.01 20:40:1 4 16c 95 2 17 0.01 20:40:1 4 18c 95 2 19 0.01 20:40:1 6 20c 90 21 5 0.01 25:50:1 5 22g 90 21 15 0.01 25:50:1 3e 29g 94 21 26 0.01 25:50:1 3e 31g 92 21 27 0.01 25:50:1 5e 33g 96 24 5 0.01 25:50:1 1.5e 35g 97 25 5 0.01 25:50:1 1.5e 37g 97 21 5 0.01 25:50:1 5f 39g 90 21 42 0.01 20:40:1 3g 43c 50 aAROMP reactions were performed in CD2Cl2 and monitored by 1H-NMR spectroscopy at room temperature. bPercent conversion determined by integration of 1H-NMR spectra unless specified otherwise. cAROMP reactions were performed in CH2Cl2, and the isolated yield was determined after flash column chromatography purification. dNR: no reaction. eReaction temperature: 50° C., solvent: CDCl3 fCatalyst: Hoveyda-Grubbs 2nd Generation catalyst 28 gReaction temperature: 50° C., solvent: CDCl3, Catalyst: 41 TABLE 2 Minimum Inhibitory Concentrations (MIC)a and HC50b 23g 30g 32g 34g 40g 36g 38g Strain (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) (μg/mL) Pseudomonas 64 >64 >64 >64 >64 128 32 aeruginosa ATCC 27853 Escherichia coli 16 64 >64 >64 >64 64 8 ATCC 25922 Bacillus cereus 8 16 >64 32 64 64 8 ATCC 10987 Staphylococcus 4 8 >64 32 16 32 4 aureus ATCC 25923 Enterococcus 4 16 >64 32 32 64 8 faecalis ATCC 19433 Enterococcus 4 16 >64 32 32 32 8 faecium ATCC 19434 HC50 256 768 >1024 192 1024 1024 512 aIndicated strains were incubated with an aqueous solution of 23g for 18 h, and the lowest concentration at which no growth is detected is reported. bHemolytic activity towards red blood cells (HC50 = concentration at which 50% of blood cells are lysed) ..



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